Scientific Publications

30 June 2021

Toward Physicochemical and Rheological Characterization of Different Injectable Hyaluronic AcidDermal Fillers Cross-Linked with Polyethylene Glycol Diglycidyl Ether

Polymers 2021, 13, 948

Nicola Zerbinati, Sabrina Sommatis, Cristina Maccario, Maria Chiara Capillo, Giulia Grimaldi, Giuseppe Alonci, Marina Protasoni, Raffaele Rauso and Roberto Mocchi


Background: Injectable hyaluronic acid (HA) dermal fillers are used to restore volume, hydration and skin tone in aesthetic medicine. HA fillers differfromeach other due to theircrosslinking technologies,with the aim to increase mechanical and biological activities. One of the most recentand promising crosslinkersis polyethylene glycol diglycidyl ether (PEGDE), used by the company MatexLab S.p.A., (Brindisi, Italy) to create the HAdermal filler PEGDEfamily. Over the last few years, several studies have beenperformed to investigate the biocompatibility and biodeg-radability of theseformulations, but little information isavailable regarding their matrix structure, rheological and physicochemicalproperties related to their crosslinking technologies, the HA con-tent or the degree of crosslinking. (2) Methods: Seven different injectable HA hydrogels were sub-jected to optical microscopic examination, cohesivity evaluation and rheological characterization in order to investigate their behavior. (3) Results: The analyzed crosslinked dermal fillers showed a fibrous “spiderweblikematrix structure, witheach medical device presentingdifferent and pecu-liar rheological features.Except forHA non crosslinked hydrogel 18 mg/mL, all showedan elastic and cohesive profile. (4) Conclusions: The comparative analysis with other literatureworks makes a preliminary characterization of these injectable medical devicespossible

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